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queuosine biosynthesis I (de novo)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
pre-queuine_1 + NADP+ <=> 7-cyano-7-carbaguanine + NADPH + H+ 1.7.1.13 preQ1 synthase

S-adenosyl-L-methionine + 7-aminomethyl-7-deazaguanosine34_in_tRNA <=> epoxyqueuosine34_in_tRNA + adenine + L-methionine + H+ 2.4.99.17 S-adenosylmethionine:tRNA ribosyltransferase-isomerase

guanine34_in_tRNA + pre-queuine_1 <=> 7-aminomethyl-7-deazaguanosine34_in_tRNA + guanine 2.4.2.29 tRNA-guanosine34 transglycosylase

queuosine34_in_tRNA + acceptor + H2O <=> epoxyqueuosine34_in_tRNA + reduced_acceptor 1.17.99.6 epoxyqueuosine reductase

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